
Uremic toxins are harmful substances which accumulate in the body when kidney function becomes impaired. Most of these toxins are produced by bacteria in the gut, by our intestinal microbiome. Kidney patients rely on medicine and dialysis to remove these toxins, but the performance of these treatments is limited. Some uremic toxins bind to blood proteins and these are not effectively removed by dialysis and there is no existing treatment on the market. In the bubble tea project, we are using different strains of bacteria capable of absorbing or degrading uremic toxins. The bacteria are encapsulated in gel beads to concentrate the cells and protect them from low pH, digestive enzymes, and other bacteria in the digestive system. These gel beads can carry some cargo (such as bacteria, binders or enzymes) and they travel through the intestines and remove uremic toxins formed by gut microbiome before they can enter the bloodstream hence preventing them from accumulating to toxic levels in the serum. This innovative treatment is called therapeutic bubble tea since kidney patients can drink the gel beads like drinking bubble tea to treat symptoms of kidney disease.
